Mendel Friedman Selected Research

Tomatine

11/2016	Antiprotozoal Effects of the Tomato Tetrasaccharide Glycoalkaloid Tomatine and the Aglycone Tomatidine on Mucosal Trichomonads.
4/2015	Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes.
2/2015	The Tomato Glycoalkaloid α-Tomatine Induces Caspase-Independent Cell Death in Mouse Colon Cancer CT-26 Cells and Transplanted Tumors in Mice.
4/2012	Structure-activity relationships of α-, β(1)-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells.
7/2009	Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells.
12/2007	Protective effect of dietary tomatine against dibenzo[a,l]pyrene (DBP)-induced liver and stomach tumors in rainbow trout.

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Mendel Friedman Research Topics

Disease

20	Neoplasms (Cancer) 11/2016 - 02/2005
7	Inflammation (Inflammations) 02/2017 - 09/2010
5	Salmonella Infections (Salmonellosis) 12/2018 - 06/2012
4	Colonic Neoplasms (Colon Cancer) 01/2018 - 09/2011
4	Leukemia 04/2015 - 02/2005
4	Septic Shock (Toxic Shock Syndrome) 08/2014 - 05/2010
4	Necrosis 03/2014 - 01/2012
3	Diarrhea 01/2020 - 05/2010
3	Obesity 12/2019 - 11/2016
3	Infections 02/2018 - 09/2017
3	Body Weight (Weight, Body) 09/2015 - 01/2003
3	Teratogenesis 01/2015 - 10/2010
3	Carcinoma (Carcinomatosis) 05/2013 - 05/2004
3	Stomach Neoplasms (Stomach Cancer) 04/2012 - 07/2005
2	Trichomonas Infections 01/2020 - 11/2016
2	Weight Gain 12/2019 - 06/2018
2	Lymphoma (Lymphomas) 04/2015 - 07/2005
2	Endotoxemia 08/2014 - 11/2013
2	Wounds and Injuries (Trauma) 08/2014 - 11/2013
2	Lung Neoplasms (Lung Cancer) 10/2012 - 07/2010
2	Atopic Dermatitis (Atopic Eczema) 10/2011 - 05/2010
2	Mastitis 10/2011 - 05/2010
2	Arthritis (Polyarthritis) 10/2011 - 05/2010
2	Vomiting 10/2011 - 05/2010
2	Edema (Dropsy) 05/2011 - 09/2010
2	Hepatocellular Carcinoma (Hepatoma) 07/2009 - 01/2007
1	Sexually Transmitted Diseases (Sexually Transmitted Disease) 01/2020
1	Weight Loss (Weight Reduction) 06/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2018
1	Autistic Disorder (Autism) 01/2018
1	Cataract (Cataracts) 01/2018
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2018
1	Chronic Renal Insufficiency 01/2018
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018
1	Multiple Sclerosis 01/2018
1	Adenocarcinoma 01/2017
1	Communicable Diseases (Infectious Diseases) 11/2016
1	Chronic Disease (Chronic Diseases) 11/2016
1	Eosinophilia 02/2016
1	Leukocytosis (Pleocytosis) 02/2016
1	Asthma (Bronchial Asthma) 02/2016
1	Skin Neoplasms (Skin Cancer) 04/2015

Drug/Important Bio-Agent (IBA)

13	Biomarkers (Surrogate Marker)IBA 12/2019 - 09/2010
6	TomatineIBA 11/2016 - 12/2007
6	Ethanol (Ethyl Alcohol)IBA 06/2012 - 02/2005
4	Proteins (Proteins, Gene)FDA Link 12/2018 - 09/2011
4	TeaIBA 09/2017 - 01/2007
4	Interleukin-6 (Interleukin 6)IBA 03/2013 - 09/2010
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2013 - 05/2011
4	Amino Acids FDA Link 10/2012 - 07/2010
3	Polysaccharides (Glycans)IBA 11/2016 - 11/2013
3	tomatidineIBA 04/2015 - 01/2003
3	LipopolysaccharidesIBA 08/2014 - 05/2011
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2013 - 09/2011
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2013 - 09/2011
3	Messenger RNA (mRNA)IBA 12/2012 - 09/2011
3	alpha-solanineIBA 07/2005 - 01/2003
3	alpha-chaconineIBA 07/2005 - 01/2003
2	AnthraquinonesIBA 01/2020 - 12/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2018 - 10/2013
2	EnzymesIBA 09/2015 - 09/2011
2	solanidineIBA 04/2015 - 01/2003
2	alpha-solamargineIBA 04/2015 - 01/2003
2	solasodineIBA 04/2015 - 01/2003
2	SmokeIBA 08/2014 - 08/2012
2	GalactosamineIBA 08/2014 - 11/2013
2	Cysteine (L-Cysteine)FDA Link 08/2014 - 10/2010
2	Shiga Toxin (Shigella Toxin)IBA 07/2014 - 08/2010
2	FlavonoidsIBA 10/2012 - 01/2007
2	Insulin (Novolin)FDA Link 08/2012 - 01/2012
2	CytokinesIBA 06/2012 - 09/2011
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 06/2012 - 09/2011
2	SuperantigensIBA 10/2011 - 05/2010
2	Anticarcinogenic AgentsIBA 01/2007 - 07/2005
2	Phorbol EstersIBA 05/2005 - 02/2005
2	alpha-tomatineIBA 05/2004 - 01/2003
1	Beclin-1IBA 12/2018
1	GoldIBA 06/2018
1	Food Additives (Food Additive)IBA 02/2018
1	Tryptophan (L-Tryptophan)FDA Link 01/2018
1	InflammasomesIBA 02/2017
1	Immunoglobulin A (IgA)IBA 01/2017
1	turmeric extractIBA 01/2017
1	OvalbuminIBA 02/2016
1	Anti-Asthmatic Agents (Antiasthmatic Drugs)IBA 02/2016
1	CreatinineIBA 09/2015
1	AdiponectinIBA 09/2015
1	Urea (Carbamide)FDA LinkGeneric 09/2015
1	CholesterolIBA 09/2015
1	Triglycerides (Triacylglycerol)IBA 09/2015
1	Glutamic Acid (Glutamate)FDA Link 09/2015
1	LeptinIBA 09/2015
1	Oxaloacetic Acid (Oxalacetic Acid)IBA 09/2015
1	Pyruvic Acid (Pyruvate)IBA 09/2015
1	Transaminases (Aminotransferases)IBA 09/2015
1	TrisaccharidesIBA 04/2015

Therapy/Procedure

2	Intraperitoneal Injections 06/2012 - 09/2010
1	Therapeutics 01/2018
1	Oral Administration 02/2016